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The science behind Activflex

ActivFlex, an Australian-made topical gel, promises temporary relief from minor aches and pains associated with arthritis, muscle strains, and joint inflammation. But how effective is it, and what science backs these claims? Let's delve into the ingredients and their mechanisms of action.

Menthol: The Cooling Counterirritant

Menthol is the primary ingredient responsible for ActivFlex's signature cooling sensation. Scientific evidence suggests menthol works through a fascinating concept called counterirritation.^[1] Here's the breakdown:

• Triggering the Cool Response: Menthol binds to TRPM8 receptors in the skin, normally activated by cold temperatures. This triggers these receptors to send "cold" signals to the brain, even in the absence of an actual temperature drop.
• Pain Relief Through Counterirritation: The intense cooling sensation acts as a counterirritant, essentially distracting the nervous system from the original pain signals. The brain prioritises the strong cooling feeling over the dull ache, offering temporary relief.^[2]

This mechanism is supported by a 2018 study published in the journal "Seminars in Musculoskeletal Medicine" which highlights the role of TRPM8 channels in menthol's pain-relieving effects.^[1]

Methyl Salicylate: Targeting Inflammation

The second key ingredient, methyl salicylate, plays a different role. It's a salicylate, similar to aspirin, and functions as a mild topical anti-inflammatory agent.^[3] Here's how it works:

• Inhibiting Prostaglandins: Methyl salicylate works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins.^[3] These prostaglandins are inflammatory chemicals that contribute to pain and swelling.
• Reduced Inflammation, Reduced Pain: By reducing prostaglandin production, methyl salicylate helps lessen inflammation and the associated pain in the underlying tissues.

Aloe Vera: Soothing and Healing

Aloe vera is well-known for its soothing, anti-inflammatory, and wound-healing properties. It contains various bioactive compounds, such as polysaccharides, vitamins, and enzymes, which contribute to its therapeutic effects. Aloe vera helps to reduce skin inflammation, promote wound healing, and provide hydration to the skin.^[4]

Vitamin E: Antioxidant and Skin Protector

Vitamin E is a powerful antioxidant that protects the skin from oxidative damage caused by free radicals.^[5] It helps to stabilise cell membranes and supports skin repair and regeneration. Vitamin E also has moisturising properties, which help to maintain skin hydration and prevent dryness, making it particularly beneficial for maintaining healthy skin while using topical treatments. Its anti-inflammatory properties further contribute to reducing swelling and redness associated with injuries.

Peppermint Oil: Cooling and Analgesic

Peppermint oil enhances ActivFlex's pain-relieving properties with its cooling and analgesic effects due to menthol. It is effective in reducing muscle pain, headaches, and joint discomfort.^[6][7]

Eucalyptus Oil: Anti-Inflammatory and Antimicrobial

Eucalyptus oil is known for its anti-inflammatory and pain-relieving benefits, making it effective for sore muscles and joint pain.^[8]

Thyme Oil: Anti-Inflammatory

Thyme oil's anti-inflammatory and antioxidant benefits are useful for treating arthritis and promoting skin repair.^[9]

Synergistic Effects for Enhanced Pain Relief

The combination of menthol, methyl salicylate, aloe vera, vitamin E, and essential oils in ActivFlex provides a multifaceted approach to pain relief:

• Effective Relief: Menthol and essential oils provide a rapid cooling effect that quickly alleviates pain.
• Sustained Action: Methyl salicylate offers long-lasting pain relief through its anti-inflammatory and analgesic properties.
• Skin Health: Aloe vera, vitamin E, and essential oils ensure that the skin remains hydrated and healthy, reducing the risk of irritation from frequent application.